Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease
Identifieur interne : 000562 ( Main/Corpus ); précédent : 000561; suivant : 000563Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease
Auteurs : A. E. Dias ; E. R. Barbosa ; K. Coracini ; F. Maia ; M. A. Marcolin ; F. FregniSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2006-02.
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Abstract
Objective – To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on vocal function in Parkinson's disease (PD). Material and methods – Two different sets of rTMS parameters were investigated on 30 patients with PD: active or sham 15 Hz rTMS of the left dorsolateral prefrontal cortex (LDLPFC) (110% of motor threshold (MT), 3000 pulses per session) and active 5 Hz rTMS of the primary motor cortex (M1)‐mouth area (90% MT, 2250 pulses per session). A blind rater evaluated speech characteristics (acoustic and perceptual analysis of voice) and voice‐related quality of life (V‐RQOL). Results – rTMS of LDLPFC resulted in mood amelioration and subjective improvement of the V‐RQOL only (71.9% improvement, P < 0.001), but not in objective measures such as fundamental frequency (P = 0.86) and voice intensity (P = 0.99). On the other hand, rTMS of M1‐mouth induced a significant improvement of the fundamental frequency (12.9% for men and 7.6% for women, P < 0.0001) and voice intensity (20.6%, P < 0.0001). Conclusions – Our findings provide initial evidence that rTMS of the primary motor cortex might yield a beneficial effect on vocal function in PD.
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DOI: 10.1111/j.1600-0404.2005.00558.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title><author><name sortKey="Dias, A E" sort="Dias, A E" uniqKey="Dias A" first="A. E." last="Dias">A. E. Dias</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Barbosa, E R" sort="Barbosa, E R" uniqKey="Barbosa E" first="E. R." last="Barbosa">E. R. Barbosa</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Coracini, K" sort="Coracini, K" uniqKey="Coracini K" first="K." last="Coracini">K. Coracini</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Maia, F" sort="Maia, F" uniqKey="Maia F" first="F." last="Maia">F. Maia</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Marcolin, M A" sort="Marcolin, M A" uniqKey="Marcolin M" first="M. A." last="Marcolin">M. A. Marcolin</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Fregni, F" sort="Fregni, F" uniqKey="Fregni F" first="F." last="Fregni">F. Fregni</name><affiliation><mods:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1148F20CB47CCCD10E4AA2AE43131689EAE8A220</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1111/j.1600-0404.2005.00558.x</idno><idno type="url">https://api.istex.fr/document/1148F20CB47CCCD10E4AA2AE43131689EAE8A220/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000562</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title><author><name sortKey="Dias, A E" sort="Dias, A E" uniqKey="Dias A" first="A. E." last="Dias">A. E. Dias</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Barbosa, E R" sort="Barbosa, E R" uniqKey="Barbosa E" first="E. R." last="Barbosa">E. R. Barbosa</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Coracini, K" sort="Coracini, K" uniqKey="Coracini K" first="K." last="Coracini">K. Coracini</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Maia, F" sort="Maia, F" uniqKey="Maia F" first="F." last="Maia">F. Maia</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Marcolin, M A" sort="Marcolin, M A" uniqKey="Marcolin M" first="M. A." last="Marcolin">M. A. Marcolin</name><affiliation><mods:affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Fregni, F" sort="Fregni, F" uniqKey="Fregni F" first="F." last="Fregni">F. Fregni</name><affiliation><mods:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-02">2006-02</date><biblScope unit="volume">113</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="92">92</biblScope><biblScope unit="page" to="99">99</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">1148F20CB47CCCD10E4AA2AE43131689EAE8A220</idno><idno type="DOI">10.1111/j.1600-0404.2005.00558.x</idno><idno type="ArticleID">ANE558</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>repetitive transcranial magnetic stimulation</term><term>speech dysfunction</term><term>vocal function</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective – To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on vocal function in Parkinson's disease (PD). Material and methods – Two different sets of rTMS parameters were investigated on 30 patients with PD: active or sham 15 Hz rTMS of the left dorsolateral prefrontal cortex (LDLPFC) (110% of motor threshold (MT), 3000 pulses per session) and active 5 Hz rTMS of the primary motor cortex (M1)‐mouth area (90% MT, 2250 pulses per session). A blind rater evaluated speech characteristics (acoustic and perceptual analysis of voice) and voice‐related quality of life (V‐RQOL). Results – rTMS of LDLPFC resulted in mood amelioration and subjective improvement of the V‐RQOL only (71.9% improvement, P < 0.001), but not in objective measures such as fundamental frequency (P = 0.86) and voice intensity (P = 0.99). On the other hand, rTMS of M1‐mouth induced a significant improvement of the fundamental frequency (12.9% for men and 7.6% for women, P < 0.0001) and voice intensity (20.6%, P < 0.0001). Conclusions – Our findings provide initial evidence that rTMS of the primary motor cortex might yield a beneficial effect on vocal function in PD.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>A. E. Dias</name><affiliations><json:string>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</json:string></affiliations></json:item><json:item><name>E. R. Barbosa</name><affiliations><json:string>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</json:string></affiliations></json:item><json:item><name>K. Coracini</name><affiliations><json:string>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</json:string></affiliations></json:item><json:item><name>F. Maia</name><affiliations><json:string>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</json:string></affiliations></json:item><json:item><name>M. A. Marcolin</name><affiliations><json:string>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</json:string></affiliations></json:item><json:item><name>F. Fregni</name><affiliations><json:string>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>repetitive transcranial magnetic stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>speech dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>vocal function</value></json:item></subject><articleId><json:string>ANE558</json:string></articleId><language><json:string>eng</json:string></language><abstract>Objective – To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on vocal function in Parkinson's disease (PD). Material and methods – Two different sets of rTMS parameters were investigated on 30 patients with PD: active or sham 15 Hz rTMS of the left dorsolateral prefrontal cortex (LDLPFC) (110% of motor threshold (MT), 3000 pulses per session) and active 5 Hz rTMS of the primary motor cortex (M1)‐mouth area (90% MT, 2250 pulses per session). A blind rater evaluated speech characteristics (acoustic and perceptual analysis of voice) and voice‐related quality of life (V‐RQOL). Results – rTMS of LDLPFC resulted in mood amelioration and subjective improvement of the V‐RQOL only (71.9% improvement, P > 0.001), but not in objective measures such as fundamental frequency (P = 0.86) and voice intensity (P = 0.99). On the other hand, rTMS of M1‐mouth induced a significant improvement of the fundamental frequency (12.9% for men and 7.6% for women, P > 0.0001) and voice intensity (20.6%, P > 0.0001). Conclusions – Our findings provide initial evidence that rTMS of the primary motor cortex might yield a beneficial effect on vocal function in PD.</abstract><qualityIndicators><score>7.044</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1186</abstractCharCount><pdfWordCount>4420</pdfWordCount><pdfCharCount>28956</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>177</abstractWordCount></qualityIndicators><title>Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>113</volume><publisherId><json:string>ANE</json:string></publisherId><pages><total>8</total><last>99</last><first>92</first></pages><issn><json:string>0001-6314</json:string></issn><issue>2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1600-0404</json:string></eissn><title>Acta Neurologica Scandinavica</title><doi><json:string>10.1111/(ISSN)1600-0404</json:string></doi></host><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1111/j.1600-0404.2005.00558.x</json:string></doi><id>1148F20CB47CCCD10E4AA2AE43131689EAE8A220</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1148F20CB47CCCD10E4AA2AE43131689EAE8A220/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1148F20CB47CCCD10E4AA2AE43131689EAE8A220/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1148F20CB47CCCD10E4AA2AE43131689EAE8A220/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2006</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title><author><persName><forename type="first">A. E.</forename><surname>Dias</surname></persName><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation></author><author><persName><forename type="first">E. R.</forename><surname>Barbosa</surname></persName><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation></author><author><persName><forename type="first">K.</forename><surname>Coracini</surname></persName><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation></author><author><persName><forename type="first">F.</forename><surname>Maia</surname></persName><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation></author><author><persName><forename type="first">M. A.</forename><surname>Marcolin</surname></persName><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation></author><author><persName><forename type="first">F.</forename><surname>Fregni</surname></persName><affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA</affiliation></author></analytic><monogr><title level="j">Acta Neurologica Scandinavica</title><idno type="pISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><idno type="DOI">10.1111/(ISSN)1600-0404</idno><imprint><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-02"></date><biblScope unit="volume">113</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="92">92</biblScope><biblScope unit="page" to="99">99</biblScope></imprint></monogr><idno type="istex">1148F20CB47CCCD10E4AA2AE43131689EAE8A220</idno><idno type="DOI">10.1111/j.1600-0404.2005.00558.x</idno><idno type="ArticleID">ANE558</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective – To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on vocal function in Parkinson's disease (PD). Material and methods – Two different sets of rTMS parameters were investigated on 30 patients with PD: active or sham 15 Hz rTMS of the left dorsolateral prefrontal cortex (LDLPFC) (110% of motor threshold (MT), 3000 pulses per session) and active 5 Hz rTMS of the primary motor cortex (M1)‐mouth area (90% MT, 2250 pulses per session). A blind rater evaluated speech characteristics (acoustic and perceptual analysis of voice) and voice‐related quality of life (V‐RQOL). Results – rTMS of LDLPFC resulted in mood amelioration and subjective improvement of the V‐RQOL only (71.9% improvement, P < 0.001), but not in objective measures such as fundamental frequency (P = 0.86) and voice intensity (P = 0.99). On the other hand, rTMS of M1‐mouth induced a significant improvement of the fundamental frequency (12.9% for men and 7.6% for women, P < 0.0001) and voice intensity (20.6%, P < 0.0001). Conclusions – Our findings provide initial evidence that rTMS of the primary motor cortex might yield a beneficial effect on vocal function in PD.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>repetitive transcranial magnetic stimulation</term></item><item><term>speech dysfunction</term></item><item><term>vocal function</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/1148F20CB47CCCD10E4AA2AE43131689EAE8A220/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Munksgaard International Publishers</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0404</doi><issn type="print">0001-6314</issn><issn type="electronic">1600-0404</issn><idGroup><id type="product" value="ANE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA NEUROLOGICA SCANDINAVICA">Acta Neurologica Scandinavica</title></titleGroup></publicationMeta><publicationMeta level="part" position="02002"><doi origin="wiley">10.1111/ane.2006.113.issue-2</doi><numberingGroup><numbering type="journalVolume" number="113">113</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2006-02">February 2006</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1600-0404.2005.00558.x</doi><idGroup><id type="unit" value="ANE558"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Original articles</title></titleGroup><eventGroup><event type="firstOnline" date="2006-01-11"></event><event type="publishedOnlineFinalForm" date="2006-01-11"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="92">92</numbering><numbering type="pageLast" number="99">99</numbering></numberingGroup><correspondenceTo>Felipe Fregni, Center for Non‐invasive Brain Stimulation, Beth Israel Deaconess Medical Center, 330 Brookline Ave – KS 433, Boston, MA 02215, USA.
Tel.: +1‐617‐667‐5272
Fax: +1‐617‐975‐5322
e‐mail: <email>ffregni@bidmc.harvard.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANE.ANE558.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication November 4, 2005</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title><title type="shortAuthors"><b>Dias et al.</b></title><title type="short"><b>Effects of rTMS on voice and speech in PD</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>A. E.</givenNames><familyName>Dias</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>E. R.</givenNames><familyName>Barbosa</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>K.</givenNames><familyName>Coracini</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>F.</givenNames><familyName>Maia</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>M. A.</givenNames><familyName>Marcolin</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>F.</givenNames><familyName>Fregni</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="BR"><unparsedAffiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Parkinson's disease</keyword><keyword xml:id="k2">repetitive transcranial magnetic stimulation</keyword><keyword xml:id="k3">speech dysfunction</keyword><keyword xml:id="k4">vocal function</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!-- Dias AE, Barbosa ER, Coracini K, Maia F, Marcolin MA, Fregni F. Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease. Acta Neurol Scand 2006: 113: 92–99. © 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard. --><p><b>Objective – </b> To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on vocal function in Parkinson's disease (PD).</p><p><b>Material and methods – </b> Two different sets of rTMS parameters were investigated on 30 patients with PD: active or sham 15 Hz rTMS of the left dorsolateral prefrontal cortex (LDLPFC) (110% of motor threshold (MT), 3000 pulses per session) and active 5 Hz rTMS of the primary motor cortex (M1)‐mouth area (90% MT, 2250 pulses per session). A blind rater evaluated speech characteristics (acoustic and perceptual analysis of voice) and voice‐related quality of life (V‐RQOL).</p><p><b>Results – </b> rTMS of LDLPFC resulted in mood amelioration and subjective improvement of the V‐RQOL only (71.9% improvement, <i>P</i> < 0.001), but not in objective measures such as fundamental frequency (<i>P</i> = 0.86) and voice intensity (<i>P</i> = 0.99). On the other hand, rTMS of M1‐mouth induced a significant improvement of the fundamental frequency (12.9% for men and 7.6% for women, <i>P</i> < 0.0001) and voice intensity (20.6%, <i>P</i> < 0.0001).</p><p><b>Conclusions – </b> Our findings provide initial evidence that rTMS of the primary motor cortex might yield a beneficial effect on vocal function in PD.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated"><title>Effects of rTMS on voice and speech in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">A. E.</namePart><namePart type="family">Dias</namePart><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. R.</namePart><namePart type="family">Barbosa</namePart><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Coracini</namePart><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Maia</namePart><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Marcolin</namePart><affiliation>Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Fregni</namePart><affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Munksgaard International Publishers</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2006-02</dateIssued><edition>Accepted for publication November 4, 2005</edition><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Objective – To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on vocal function in Parkinson's disease (PD). Material and methods – Two different sets of rTMS parameters were investigated on 30 patients with PD: active or sham 15 Hz rTMS of the left dorsolateral prefrontal cortex (LDLPFC) (110% of motor threshold (MT), 3000 pulses per session) and active 5 Hz rTMS of the primary motor cortex (M1)‐mouth area (90% MT, 2250 pulses per session). A blind rater evaluated speech characteristics (acoustic and perceptual analysis of voice) and voice‐related quality of life (V‐RQOL). Results – rTMS of LDLPFC resulted in mood amelioration and subjective improvement of the V‐RQOL only (71.9% improvement, P < 0.001), but not in objective measures such as fundamental frequency (P = 0.86) and voice intensity (P = 0.99). On the other hand, rTMS of M1‐mouth induced a significant improvement of the fundamental frequency (12.9% for men and 7.6% for women, P < 0.0001) and voice intensity (20.6%, P < 0.0001). Conclusions – Our findings provide initial evidence that rTMS of the primary motor cortex might yield a beneficial effect on vocal function in PD.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>repetitive transcranial magnetic stimulation</topic><topic>speech dysfunction</topic><topic>vocal function</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>92</start><end>99</end><total>8</total></extent></part></relatedItem><identifier type="istex">1148F20CB47CCCD10E4AA2AE43131689EAE8A220</identifier><identifier type="DOI">10.1111/j.1600-0404.2005.00558.x</identifier><identifier type="ArticleID">ANE558</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Munksgaard International Publishers</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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